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We prospectively enrolled 62 consecutive women patients affected by SSc and 62 healthy women who served as controls. This cross-sectional study was performed in San Cecilio Hospital, Granada (Spain) from November 2017 to May 2019. The purpose of this study was to evaluate the association between FRAX index and FGF-23 serum levels in SSc women patients compared with healthy controls. The goal of the FRAX tool is to help clinicians better select patients for fracture-prevention treatment ( 7 ). It was developed by the WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UK, in collaboration with other scientific societies and is based on specific country data for fracture and death rates for women and men over the age of 40 yr. This tool uses selected clinical information as well as femoral neck BMD to predict the 10-yr probability of a major osteoporotic fracture and a hip fracture in an individual. In 2008, with further refinement of the clinical application of bone mineral density (BMD) measurement, the World Health Organization (WHO) released an online tool for fracture risk assessment called FRAX ( 6 ). Recently, elevated serum levels of FGF-23 have been reported to be associated with an increased risk of osteoporotic fractures in elderly Swedish men ( 5 ). In addition, FGF-23 is reported to inhibit renal 1 hydroxylase expression which reduces the production of 1,25 dihydroxyvitamin D leading to a diminished calcium and phosphate gastrointestinal absorption ( 4 ).
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The main target of FGF-23 is the kidney where FGF-23 reduces the expression or insertion of sodium phosphate transporters within renal proximal tubular membranes so that phosphate can be excreted ( 3 ).
#Ssc service utility 4.50 skin
Patients with SSc are also at high risk of osteoporosis and fragility fractures as a result of disease-specific alterations including renal insufficiency, gastrointestinal malabsorption, decreased vitamin D synthesis in the fibrotic skin and immobilization due to flexion contractures of the joints and muscle wasting ( 2 ).įibroblast growth factor-23 (FGF-23) is a known regulator of phosphate homeostasis, and most of it is produced by bone-resident osteocytes. Systemic sclerosis (SSc) is a multisystemic disease featured by vascular and immunological disorders along with an excessive accumulation of the components of the connective tissue that cause cutaneous sclerosis and fibrosis of different organs ( 1 ).
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FGF-23 could be a promising biomarker for detecting risk fracture in SSc women patients. Conclusions: This study shows that FGF-23 status is associated with FRAX index in women with SSc. FGF-23 levels were positively associated with FRAX index within the study group. The FRAX scoring tool was applied using the on-line calculator (Results: Even though there was no significant difference in FGF-23 levels between SSc women patients and healthy controls (78.2 ± 60.5 vs 80.3 ± 56.3 pg/mL, p = 0.662). FGF-23 serum concentration was evaluated by indirect enzyme-linked immunosorbent assay.
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Sixty-two women with SSc and 62 age and sex matched healthy controls were included in this study. Methodology: This cross-sectional study was performed in San Cecilio Hospital, Granada (Spain) from November 2017 to May 2019. Introduction/Background: The purpose of this study was to evaluate the association between Fracture Risk Assessment Tool (FRAX) and serum fibroblast grow factor-23 (FGF-23) levels in SSc women patients compared with healthy controls.
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